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Renin pAb

Renin pAb

Cat no: BS6722

Supplier: Bioworld Technology, Inc.
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Renin is a highly specific endopeptidase that mediates the cleavage of the circulating substrate angiotensinogen to yield Angiotensin I. Angiotensin-converting enzyme I (ACE) then completes the conversion from Angiotensin I to Angiotensin II which is significant in the regulation of electrolyte balance and blood pressure. Sympathetic stimulation ((beta)1-adrenergic receptors), renal artery hypotension and decreases in sodium delivery to the distal tubules of the kidney signal the release of Renin. The Renin-Angiotensin system (RAS) is essential for regulating blood volume, arterial pressure and normal cardiac and vascular function. Renin is synthesized and secreted by modified smooth muscle cells in the juxtaglomerular apparatus (JGA) of the kidney. Expression of Renin in other tissues, including brain, has been verified although the homeostatic role it may play is yet to be firmly established.
Catalogue number: BS6722
Reactivities: Human
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P00797
Dilutions: WB: 1:500~1:2000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Recombinant full length Human Renin.
Species: Renin pAb detects endogenous levels of Renin protein.
Molecular weight: ~ 45 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; FLJ10761; HNFJ2; REN; Ren1; RENI; Renin; Renin precursor renal;
Additional info: For research use only, not for use in diagnostic procedure.

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