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RGS10 pAb

RGS10 pAb

Cat no: BS5895

Supplier: Bioworld Technology, Inc.
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Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. In mammals, G protein (alpha), (beta) and (gamma) polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their (alpha) subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Four G(alpha) GTPase-activating proteins (GAPs) have been identified and are designated RGS1 (regulator of G protein signaling), RGS4, RGS10 and GAIP (G(alpha)-interacting protein). Each of these proteins has been shown to deactivate specific G(alpha) isoforms by increasing the rate at which they convert GTP to GDP. RGS1, RGS4 and GAIP bind tightly to and exhibit GAP activity towards G(alpha) i, G(alpha) o and G(alpha) t, but not G(alpha) s. RGS10 increases the GTP hydrolytic activity of several members of the G(alpha) i sub-family, including G(alpha) i-3, G(alpha) z and G(alpha) o.
Catalogue number: BS5895
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: O43665
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 357-402 of Human RGS10.
Species: RGS10 pAb detects endogenous levels of RGS10 protein.
Molecular weight: ~ 20 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Regulator of G-protein signaling 10
Additional info: For research use only, not for use in diagnostic procedure.

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