RGS2 pAb

Heterotrimeric G proteins function to relay information from cell surface receptors to intracellular effectors. In mammals, G protein a, b and g polypeptides are encoded by at least 16, 4 and 7 genes, respectively. Most interest in G proteins has been focused on their a subunits, since these proteins bind and hydrolyze GTP and most obviously regulate the activity of the best studied effectors. Several Ga GTP-ase activating proteins (GAPs) have been identified and are designated RGS1, RGS2, RGS4, RGS7, RGS9, RGS10 and GAIP (G(alpha)-interacting protein). Each of these proteins has been shown to deactivate specific G(alpha) isoforms by increasing the rate at which they convert GTP to GDP. RGS2 has been shown to be an inhibitor of G(alpha)q function. RGS9 expression is restricted to photoreceptor cells and RGS9 has been shown to regulate G(alpha)t.

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SPECIFICATIONS

Catalog Number

BS6724

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human RGS2.

Species

RGS2 pAb detects endogenous levels of RGS2 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

P41220

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 24 kDa

Alternative Names

Basic helix-loop-helix phosphoprotein G0S8; Cell growth inhibiting protein 31; Cell growth-inhibiting gene 31 protein; G0 to G1 switch regulatory 8 24; G0/G1 switch regulatory protein 8; GOS8; OTTHUMP00000060765; Regulator of G protein signaling 2; Regulator of G protein signalling 2 24; Regulator of G-protein signaling 2; Regulators of G protein signaling XRGSVI; RGS 2; RGS2; RGS2; RGS2;