The genes encoding for mammalian ribosomal proteins comprise multigene families that consist predominantly of multiple processed pseudogenes and one functional intro-containing gene within their coding regions. The rpS6 gene gives rise to Ribosomal protein S6 (also designated RPS6) and Ribosomal protein L28. Sequence comparison has identified RPS6 as the equivalent of the ribosomal protein S10 from Saccharomyces cerevisiae. The sequence comparison of ribosomal proteins from evolutionarily distant eukaryotes, such as yeast and human, indicates that the structure and the function are highly conserved.