Bacterial pathogens deliver type III effector proteins into the plant cell during infection. Plants express disease resistance (R) proteins that respond specifically to a particular type III effector by activating immune responses. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction. RPS2 (resistance to Pseudomonas syringae protein 2) is a 909 amino acid plasma membrane protein with leucine-rich repeat, leucine zipper and P loop domains that confers resistance to Pseudomonas syringae infection by interacting with the avirulence gene AvrRpt2. Belonging to the disease resistance NB-LRR family, RPS2 directly associates with RIN4, which triggers plant resistance when RIN4 is degraded by AvrRpt2.