RUNX-2 (D198) pAb

Cat no: BS8734

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2(alpha)B, CBFA2), RUNX2 (also designated AML-3, PEBP2(alpha)A, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBP(alpha)C, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.

Catalogue number:	BS8734
Reactivities:	Human, Mouse, Rat
Hosts:	Rabbit
Applications:	Immunohistochemistry, Western Blot
Size:	100ug/100ul
Swiss prot:	Q13950
Dilutions:	WB: 1:500~1:1000 IHC: 1:50~1:200
Form:	liquid
Storage buffer:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration:	1ug/ul
Antigen:	Synthetic peptide, corresponding to amino acids 166-220 of Human RUNX-2.
Species:	RUNX-2 (D198) pAb detects endogenous levels of RUNX-2 protein.
Molecular weight:	~ 50 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp:	Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names:	CASP3; APOPAIN; CASP-3; CPP-32; CPP32; CPP32B; EC 3.4.22.-; SCA-1; YAMA;
Additional info:	For research use only, not for use in diagnostic procedure.

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RUNX-2 (D198) pAb

Cat no: BS8734

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