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SANT-2 (N-3,4,5-triethoxybenzamide)

SANT-2 (N-3,4,5-triethoxybenzamide)

Cat no: 045270

Supplier: United States Biological
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Cell permeable potent smoothened (Smo) antagonist. Inhibits wt and oncogenic Smo. Tool to study hedgehog (Hh) signaling pathway. SAG activity inhibitor. Gli1 reporter gene expression inhibitor. Suppresses the Shh-dependent translocation of Smo to the primary cilium. Potential tumor growth blocker. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Stable for at least 2 years after receipt when stored at -20 degrees C. Store solutions at -20 degrees C in the dark.
Catalogue number: 045270
Size: 1mg
Purity: >95% (NMR)
Alternative names: N--3,4,5-triethoxybenzamide
References: Product Reference: ?Small molecule modulation of Smoothened activity: J.K. Chen, et al.; PNAS 99, 14071 (2002) ?Targeting the Hedgehog pathway in cancer: L.L. Rubin & F.J. de Sauvage; Nat. Rev. Drug. Discov. 5, 1026 (2006) (Review) ?Evidence for allosteric interactions of antagonist binding to the smoothened receptor: C.M. Rominger, et al.; J. Pharmacol. Exp. Ther. 329, 995 (2009) ?Hedgehog signal transduction by Smoothened: pharmacologic evidence for a 2-step activation process: R. Rohatgi, et al.; PNAS 106, 3196 (2009) ?Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway: A. B

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