Secretory Leukocyte Protease Inhibitor (SLPI, ALK1, Antileukoproteinase, ALP, BLPI, HUSI, HUSI-1, HUSI-I, Mucus Proteinase Inhibitor, MPI, Protease Inhibitor WAP4, Secretory Leukocyte Peptidase Inhibitor, Seminal Proteinase Inhibitor, WAP4, WAP Four-Disul

SLPI, also known as antileukoprotease (ALP), is a 11.7kD cationic inhibitor of neutrophil elastase and to a lesser extent of cathepsin G. It is locally produced by epithelial cells in the lung, skin and other organs, by Polymorphonuclear leukocytes (PMN) and (in mice) by macrophages. In addition to its proteinase inhibitory properties that may serve to protect against proteolytic injury, it was recently shown that SLPI also displays several other functions such as antimicrobial and anti-inflammatory activities. These appear to be independent of its ability to inhibit PMN serine proteinases. SLPI has also been demonstrated to display antibacterial and antifungal activity at concentrations in which SLPI is present in mucosal secretions including those of the lung. Another possible role for SLPI is inhibition of protein-disulphide isomerase that is considered essential for invasion of a cell by the Human Immunodeficiency Virus (HIV).\n\nApplications: \nSuitable for use in Western Blot and Immunoprecipitation. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1:10\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S0635-01C

Size

100ug

Applications

IP, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

1. Kramps, J et al; Interactions among stimulated human polymorphonuclear leucocytes, released elastase and bronchial antileucoprotease. Clin Sci 1988, 75:53.

Additional Info

Recognizes human secretory leukocyte proteinase inhibitor (SLPI).