SEMA3C (E750) pAb

SEMA3C (also designated Semaphorin 3C, Semaphorin E, SEMAE, SemE,sema domain, immunoglobulin domain (Ig) and short basic domain, secreted)is an ubiquitous protein of approximately 70 kDa that mediates axonal guidance, repulsive gradients, induction of growth cone collapse and cell survival/death. Secreted SEMA3C favors survival and neuritogenesis of cultured cerebellar granule neurons (CGNs). SEMA3C from macrophages and fibroblasts that selectively directs against sympathetic nerve fibers may be one element responsible for reduced sympathetic innervation in rheumatoid arthritis tissue.SEMA3C mutant mice die within hours after birth from congenital cardiovascular defects consisting of interruption of the aortic arch and improper septation of the cardiac outflow tract. SEMA3C is expressed in the cardiac outflow ract as neural crest cells and promotes crest cell migration into the proximal cardiac outflow tract.

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SPECIFICATIONS

Catalog Number

BS3705

Size

100ug/100ul

Applications

IHC

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 713-768 of Human SEMA3C.

Species

SEMA3C (E750) pAb detects endogenous levels of SEMA3C protein.

Dilutions

IHC: 1:50~1:200

Swiss Prot

Q99985

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul