Separase (A795) Peptide

Cat no: AP0374P

Supplier: Bioworld Technology, Inc.

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Separase is a cysteine protease that triggers anaphase in all eukaryotes by participating in separation of sister chromatids during mitosis. Once activated, separase hydrolyzes the SCC1 subunit of cohesin, the chromosomal protein complex responsible for sister chromatid cohesion. Separase and cohesin are highly conserved from yeasts to humans. When the cell is not dividing, separase is prevented from cleaving cohesin through its association with another protein, securin. When anaphase is signaled, the securin is ubiquitinated and hydrolyzed by APC/cyclosome, releasing the active separase. Separase is transiently activated between the two meioses and may also be involved in homolog separation.

Catalogue number:	AP0374P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q14674
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Separase (A795). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	Caspase like protein ESPL1; ESP 1; ESP1; ESPL 1; ESPL1; Extra spindle poles like 1; Extra spindle poles like 1 protein; FLJ46492; KIAA0165; Separin; Similar to fission yeast cut1and gene; SSE;
Additional info:	This peptide can be used with studies using AP0374 Separase (A795) pAb.

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Separase (A795) Peptide

Cat no: AP0374P

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