Home  >  Products  >  Serotonin Receptor 1B (5-hydroxytryptamine Receptor 1B, 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta Receptor, 5-HT-1D-beta, HTR1B, HTR1DB)
Serotonin Receptor 1B (5-hydroxytryptamine Receptor 1B, 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta Receptor, 5-HT-1D-beta, HTR1B, HTR1DB)

Serotonin Receptor 1B (5-hydroxytryptamine Receptor 1B, 5-HT-1B, 5-HT1B, S12, Serotonin 1D beta Receptor, 5-HT-1D-beta, HTR1B, HTR1DB)

Cat no: S1001-19A2

Supplier: United States Biological
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This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:8000 Western Blot: 1-3ug/ml, observed in human brain lysates on ~48kD bands Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1001-19A2
Reactivities: Human, Mouse, Rat, Bovine, Canine, Porcine
Hosts: Goat
Applications: ELISA, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M, Vaugeois JM, Nomikos GG, Greengard P. Alterations in 5-HT1B receptor function by p11 in depression-like states. Science. 2006 Jan 6;311(5757):77-80.
Additional info: Recognizes human HTR1B. Species sequence homology: Bovine, canine, feline, mouse, porcine and rat.

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