Home  >  Products  >  SFRP1 (Secreted Apoptosis-related Protein 2, SARP-2, Secreted Frizzled-related Protein 1, sFRP-1, FRP-1, SARP2, FRP1, FRP)
SFRP1 (Secreted Apoptosis-related Protein 2, SARP-2, Secreted Frizzled-related Protein 1, sFRP-1, FRP-1, SARP2, FRP1, FRP)

SFRP1 (Secreted Apoptosis-related Protein 2, SARP-2, Secreted Frizzled-related Protein 1, sFRP-1, FRP-1, SARP2, FRP1, FRP)

Cat no: S1012-86G

Supplier: United States Biological
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SFRP1 encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling; epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer. Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:1000 Immunohistochemistry (Paraffin): 3-6ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1012-86G
Reactivities: Human, Mouse, Bovine
Hosts: Goat
Applications: ELISA, Immunohistochemistry
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Gumz ML, Zou H, Kreinest PA, Childs AC, Belmonte LS, LeGrand SN, Wu KJ, Luxon BA, Sinha M, Parker AS, Sun LZ, Ahlquist DA, Wood CG, Copland JA Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma Clin Cancer Res. 2007 Aug 15;13(16):4740-9
Additional info: Recognizes human SFRP1. Species sequence homology: Bovine and mouse.

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