SFTPB, ID (SFTPB, SFTP3, Pulmonary surfactant-associated protein B, 18kD pulmonary-surfactant protein, 6kD protein, Pulmonary surfactant-associated proteolipid SPL(Phe))

SFTPB is the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.\n\nApplications:\nSuitable for use in Western Blot, ELISA\n\nRecommended Dilution:\nELISA: 1:1,000\nWestern Blot: 1:100-500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

041640

Size

200ul

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

P Type

Pab

Purity

Purified by Protein A affinity chromatography.

Isotype

IgG

References

Baekvad-Hansen, M., et al. Eur. Respir. J. (2010) In press :\nKim, W.J., et al. Eur. Respir. J. (2010) In press :\nSchuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)\nCho, M.H., et al. Respir. Res. 11, 30 (2010) :\nChaiworapongsa, T., et al. J. Matern. Fetal. Neonatal. Med. 21(9):663-670(2008)

Additional Info

Human

Alternative Names

SFTPB, SFTP3, Pulmonary surfactant-associated protein B, 18kD pulmonary-surfactant protein, 6kD protein, Pulmonary surfactant-associated proteolipid SPL(Phe)