SGLT-2 (Sodium Glucose Transporter 2)

The kidneys play a major role in the regulation of glucose levels. Kidneys filter approx. 180g of glucose per day from the blood, and this is mostly reabsorbed back into the blood in the proximal tubules. Typically, glucose is first absorbed within epithelium by a specific transporter protein, Sodium glucose co- transporters (SGLT), in the brush-border membrane and then it is transported out of the cell across the basolateral membranes by a facilitated sugar transporter (GLUTs). At least 3 members of SGLTs (SGLT1-3) have been cloned and characterized from various species. Individual members of this family have identical predicted secondary structures with up to 14 transmembrane domains. SGLT1-3 genes code for protein of ~659-672aa (calculated size of ~75kD). Both N and C-termini are predicted to be extracellualr.

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SPECIFICATIONS

Catalog Number

S1010-87B

Size

50ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Rat

Form

Supplied as a liquid in PBS, pH 7.4, 0.1% BSA, 40% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Wells, R.G., et al., JBC 270: 29,365-29,371 (1995). 2. Wells, R.G., et al., Am. J. Physiol. 263: F459-F465 (1992). 3. Kanai, Y., et al., J. Clin. Invest. 93: 397-404 (1994). 4. Wright, E., Am. J. Physiol. Renal Physiol. 280: F10-F18 (2001) (review).

Additional Info

Recognizes rat SGLT-2. No significant sequence homology exists with other SGLTs. Species sequence homology: mouse 86% .