SHB is an adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. It may play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. It may also play a role in T cell antigen receptor/TCR signaling, interleukin 2 signaling, apoptosis and neuronal cells differentiation by mediating basic FGF and NGF-induced signaling cascades, and may also regulate IRS1 and IRS2 signaling in insulin producing cells.
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