SHIP1 (P1167) Peptide

Cat no: BS1321P

Supplier: Bioworld Technology, Inc.

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Description
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The major translational product of the v-Fms oncogene, originally isolated from the McDonough strain of feline sarcoma virus, has been identified as a glycoprotein with intrinsic tyrosine kinase activity. The v-Fms human cellular homolog, c-Fms, has been molecularly cloned and mapped to band q34 on chromosome 5, and identified as the receptor for hematopoietic ligand, CSF-1. Ligand-induced activation of the intrinsic CSF-1R protein tyrosine kinase triggers its interaction with cytoplasmic effector molecules. One such effector molecule, SHIP-1 p145 (SH2-containing-inositol phosphatase), associates with activated Fms. SHIP-1 contains two phosphotyrosine-binding domains (PTB), a unique amino-terminal SH2 domain, a proline-rich region and two highly conserved motifs found among inositol phosphate 5-phosphatases. SHIP-1 displays both phosphatidylinositol 3,4,5-triphosphate and inositol 1,3,4,5-tetrakisphosphate polyphosphate 5-phosphatase activity. Evidence suggests that SHIP-1 may modulate Ras signaling in addition to inositol signaling pathways.

Catalogue number:	BS1321P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q92835
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide SHIP1 (P1167). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	INPP5D; HP51CN; MGC104855; MGC142140; MGC142142; SHIP; SHIP1; SIP-145
Additional info:	This peptide can be used with studies using BS1321 SHIP1 (P1167) pAb.

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SHIP1 (P1167) Peptide

Cat no: BS1321P

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