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SHP-1 (K530) Peptide

Cat no: BS1424P

SHP-1 (K530) Peptide

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.

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SPECIFICATIONS

Catalog Number

BS1424P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide SHP-1 (K530). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

P29350

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS1424 SHP-1 (K530) pAb.

Alternative Names

PTPN6; HCP; HCPH; HPTP1C; PTP-1C; SH-PTP1; SHP-1; SHP-1L; SHP1; SH-PTP1; \n\n\n\n

SUPPLIER INFO

Bioworld Technology, Inc.

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