Siah-1/2 (Q210) Peptide

Cat no: BS2327P

Supplier: Bioworld Technology, Inc.

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Description
Additional Information

SIAH, the human homologue of the Drosophila seven in absentia (sina) gene, is a tumor suppressor protein that is expressed in intestinal epithelium and activated during apoptosis. Human SIAH proteins are produced as two distinct gene products, SIAH-1, and a slightly larger protein SIAH-2, which share a highly conserved C-terminal sequence and differ in their N-terminal regions. SIAH-1 is a 32 kDa protein that contains an N-terminal RING-finger domain, which is required for proteolysis, and a cystein-rich C-terminal domain, which regulates oligomerization and SIAH binding to target proteins. As a tumor suppressor, SIAH-1 binds DCC (deleted in colorectal cancer) and regulates DCC degradation via the ubiquitin-proteasome pathway. SIAH-1 also binds a Bcl-2 related protein, Bag-1, thereby inhibiting cell growth. The majority of SIAH-1 is localized to the nucleus, however a small percentage is detected in the cytoplasm. This nuclear localization suggests that SIAH proteins may interact with other nuclear matrix proteins and DNA.

Catalogue number:	BS2327P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q8IUQ4/O43255
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Siah-1/2 (Q210). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	SIAH1; HUMSIAH. Siah-1. Siah-1a. hSIAH1
Additional info:	This peptide can be used with studies using BS2327 Siah-1/2 (Q210) pAb.

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Siah-1/2 (Q210) Peptide

Cat no: BS2327P

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