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SIGIRR:Fc, Recombinant, Human (Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule)

SIGIRR:Fc, Recombinant, Human (Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule)

Cat no: 045281

Supplier: United States Biological
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SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Sequence: Signal peptide and extracellular domain of human SIGIRR (aa 1-118) are fused at the C-terminus to the Fc portion of human IgG1. Storage and Stability: Short-term Storage: +4 degrees C Long-term Storage: -20 degrees C Working aliquots are stable for up to 3 months when stored at -20 degrees C.
Catalogue number: 045281
Size: 10ug
Form: Supplied as a liquid from a 0.2um-filtered solution in PBS, pH 7.2.
Purity: >90% (SDS-PAGE)
Alternative names: Toll/Interleukin-1 Receptor 8, TIR8, Single Ig IL-1R-related Molecule

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