SIT1 (Signaling Threshold-regulating Transmembrane Adapter 1, SHP2-interacting Transmembrane Adapter Protein, Suppression-inducing Transmembrane Adapter 1, gp30/40, SIT)

Cat no: S1013-99B

Supplier: United States Biological

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Negatively regulates TCR (T-cell antigen receptor)-mediated signaling in T-cells. Involved in positive selection of T-cells. Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 1:2000 Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Catalogue number:	S1013-99B
Reactivities:	Human
Hosts:	Goat
Applications:	ELISA
Size:	100ug
Form:	Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type:	Pab
Purity:	Purified by immunoaffinity chromatography.
References:	1. Marie-Cardine A, Kirchgessner H, Bruyns E, Shevchenko A, Mann M, Autschbach F, Ratnofsky S, Meuer S, Schraven B, SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T cell activation. J Exp Med. 1999 Apr 19;189(8):1181-94.
Additional info:	Recognizes SIT1. Species sequence homology: Human.

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SIT1 (Signaling Threshold-regulating Transmembrane Adapter 1, SHP2-interacting Transmembrane Adapter Protein, Suppression-inducing Transmembrane Adapter 1, gp30/40, SIT)

Cat no: S1013-99B

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