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Six3/6 (D228) pAb

Six3/6 (D228) pAb

Cat no: BS1903

Supplier: Bioworld Technology, Inc.
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The SIX proteins (sine oculis) are a family of homeodomain transcription factors that share a conserved DNA binding domain. Two of these family members Six3 and Six6 (also designated Optx2 and Six9) are required for the specification and proliferation of the eye field in vertebrates, and, therefore, are the vertebrate homologues most closely related to the Drosophila sine oculis protein, which has an essential role in controlling compound eye development. Six3 and Six6 expression largely overlap during development of specific tissues, such as retina, hypothalamus, and pituitary. The human Six6 gene maps to chromosome 14q22.3-q23. Haploinsufficiency of Six6 may cause several developmental disorders, including bilateral anophthalmia and pituitary anomalies. The gene encoding the human Six3 protein maps to chromosome 2p21-p22, a region associated with holoprosencephaly type 2 (HPE2). Deletion of Six3 may be associated with HPE2 disorder, a common, severe malformation of the brain that results from incomplete cleavage of the forebrain during early embryogenesis.
Catalogue number: BS1903
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunofluorescence, Western Blot
Size: 100ug/100ul
Swiss prot: O95475
Dilutions: WB: 1:500~1:1000 IF: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 201-250 of Human Six3.
Species: Six3/6 (D228) pAb detects endogenous levels of Six3/6 protein.
Molecular weight: ~ 28 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: SIX3; HPE2; Homeobox protein SIX6; Homeodomain protein OPTX2; Optic homeobox 2; SIX6; OPTX2; SIX9
Additional info: For research use only, not for use in diagnostic procedure.

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