SK2 (KCa2, Kcnn2, SKCa2+, Apamin-sensitive Small Conductance Ca2+ -dependent K+ Channel)

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family of potassium channel genes. Two transcript variants encoding different isoforms have been found for this gene. \n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications have not been tested. \n\nRecommended Dilutions: \nPeptide ELISA Titer: 1:64,000\nWestern Blot: 0.3-1ug/ml ~70kD and 23kD bands observed in Human Liver lysates (calculated MW of 63.8kD according to NP_067627.2 and of 26.3kD according to NP_740721.1).\nOptimal dilutions to be determined by the researcher. \n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S1014-09M1

Size

100ug

Applications

ELISA, WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide.

P Type

Pab

Purity

Purified by peptide affinity chromatography.

Isotype

IgG

References

1.Morimoto T, Ohya S, Hayashi H, Onozaki K, Imaizumi Y, Cell-cycle-dependent regulation of Ca2+-activated K+ channel in Jurkat T-lymphocyte.Journal of pharmacological sciences 2007 May 104(1): 94-8

Additional Info

Recognizes human KCNN2. Species sequence homology: mouse, rat, canine, bovine.

Alternative Names

small conductance calcium-activated potassium channel protein 2, apamin-sensitive small-conductance Ca2+-activated potassium channel, hSK2, SKCA2, SK2, KCa2.2, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, KCNN2