Skp2 p45 (P399) Peptide

Cat no: BS1325P

Supplier: Bioworld Technology, Inc.

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The critical role that the family of regulatory proteins known as cyclins plays in eukaryotic cell cycle regulation is well established. The best characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of MPF (maturation promoting factor). Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin dependent kinase 2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DP-1 and E2F, and retinoblastoma protein p110. Two cyclin A-Cdk2 complex binding proteins, Skp1 p19 and Skp2 p45, have been described. Although the Skps (S phase kinase-associated proteins) associate with the active cyclin A-Cdk2 complex, they do not exhibit any regulatory effects on the complex. Abolition of Skp2 p45 function by either microinjection of anti-p45 antibodies or addition of antisense oligonucleotides prevents entry into S phase of both normal and transformed cells.

Catalogue number:	BS1325P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q13309
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide Skp2 p45 (P399). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	SKP2; FBL1; FBXL1; FLB1; MGC1366; P45SKP2
Additional info:	This peptide can be used with studies using BS1325 Skp2 p45 (P399) pAb.

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Skp2 p45 (P399) Peptide

Cat no: BS1325P

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