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SLC16A5 (A193) Peptide

SLC16A5 (A193) Peptide

Cat no: AP0702P

Supplier: Bioworld Technology, Inc.
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Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. MCT6 is highly expressed in the kidneys and is thought to have a specificity for bumetanide, a loop diuretic involved in the treatment of edema. The high substrate specificity of MCT6 suggests a possible role in therapeutic drug transport and trafficking across the plasma membrane.
Catalogue number: AP0702P
Applications: Block/Neutralize/Inhibit
Swiss prot: O15375
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide SLC16A5 (A193). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: MCT 5; MCT 6; MCT6; Monocarboxylate transporter 5; Monocarboxylate transporter 6; Monocarboxylic acid transporter 5; Monocarboxylic acid transporter 6; MOT6; SLC16A5; Solute carrier family 16 (monocarboxylic acid transporters) member 5; Solute carrier family 16 member 5
Additional info: This peptide can be used with studies using AP0702 SLC16A5 (A193) pAb.

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