SLC5A2 pAb

Glucose is the main source of energy for mammalian cells and its entry is mediated by various transporters. This process involves seven facilitative (GLUT-1 to -7) and 2 concentrative glucose transporters (SGLT-1, SGLT-2) and a sensor (SGLT-3). The SGLT family members use the electrochemical gradient of two sodium ions to transport one glucose molecule. The mRNA of SGLTs increase steadily from the fetal period to maturity along with an increase in their functional activity. SGLT-1 is responsible for the uptake of the dietary sugars glucose and galactose from the intestinal lumen, while SGLT-3 is involved in the detection of luminal glucose only. Both the sodium glucose co-transporters SGLT-1 and SGLT-2 are expressed in kidneys. Mutations in the gene encoding SGLT-2 result in familial renal glucosuria (FRG), an isolated disorder of proximal tubular glucose transport, characterized by abnormal urinary glucose excretion in the presence of normal blood glucose levels.

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SPECIFICATIONS

Catalog Number

BS5929

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 151-196 of Human SLC5A2.

Species

SLC5A2 pAb detects endogenous levels of SLC5A2 protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

P31639

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 73 kDa

Alternative Names

Sodium/glucose cotransporter 2; Na(+)/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2; SGLT2; SGLT-2