SLC5A4, CT (Low Affinity Sodium-Glucose Cotransporter, Sodium/Glucose Cotransporter 3, Na(+)/Glucose Cotransporter 3, Solute Carrier Family 5 Member 4, SGLT2)

SLC5A4 functions as a 73kD glucose sensor in the plasma membrane of cholinergic neurons, skeletal muscle, and smooth muscle. Glucose sensing is critical in the regulation of food intake, blood glucose levels, and enteric reflexes in mammals.\n\nApplications:\nSuitable for use in Immunohistochemistry (paraffin). Other applications not tested.\n\nRecommended Dilution:\nImmunohistochemistry (paraffin): 10-30ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control: Liver\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S5328-94L

Size

50ug

Applications

IHC

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Diez-Sampedro, A. et al. (2003) A glucose sensor hiding in a family of transporters. Proc. Natl. Acad. Sci. U. S. A. 100: 11753-11758. 2. Scheepers, A. et al. (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN. J. Parenter. Enteral Nutr. 28: 364-371.

Additional Info

Recognizes an epitope within the C-terminal region of human SLC5A4.