SLC7A5 (4F2LC, hLAT1, CD98, CD98LC, LAT1, MPE16, D16S469E, E16, 4F2 LC, 4F2 light chain, CD98 light chain, Integral membrane protein E16, L-type amino acid transporter 1, Solute carrier family 7 member 5, y+ system cationic amino acid transporter)

Solute carrier family 7 member 5, also known as Large neutral amino acids transporter small subunit 1 or SLC7A5 is a protein that in humans is encodes by the SLC7A5 gene. This gene is mapped to 16q24.2. This gene acts as an amino acid exchanger. It involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. This gene plays a role in neuronal cell proliferation (neurogenesis) in brain. It involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity.\n\nUniProt Number:\nQ01650\n\nGene ID:\nSLC7A5\n\nApplications:\nSuitable for use in Western Blot, Immunohistochemistry (Paraffin and Frozen), and Immunocytochemistry.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

145191

Size

100ug

Applications

ICC, IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Gaugitsch, H. W., Prieschl, E. E., Kalthoff, F., Huber, N. E., Baumruker, T. A novel transiently expressed, integral membrane protein linked to cell activation: molecular cloning via the rapid degradation signal AUUUA. J. Biol. Chem 267: 11267-11273, 1992.\n2. Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, P. J., Loffing, J., Shoemaker, C. B., Verrey, F. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Nature 395: 288-291, 1998.\n

Additional Info

Recognizes human, mouse and rat SLC7A5. No crossreactivity with other proteins.