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SLU7 Peptide

SLU7 Peptide

Cat no: BS5936P

Supplier: Bioworld Technology, Inc.
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In order to produce correctly spliced messenger RNA, two catalytic splicing steps are required. After catalytic step I, a major remodeling of the spliceosome occurs to establish the active site for step II. During the second step of mRNA splicing, exon 1 attacks an adenine-guanine (AG) dinucleotide at the 3' splice site. SLU7, the human homolog of the yeast step II splice factor Slu7, is required for selection of the correct AG. Human SLU7 associates with the spliceosome late in the splicing pathway prior to recognition of the 3' splice site for step II. SLU7 depletion in HeLa nuclear extract reveals that SLU7 is required to hold exon 1 tightly within the spliceosome for attack on a prespecified AG.
Catalogue number: BS5936P
Applications: Block/Neutralize/Inhibit
Swiss prot: O95391
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide SLU7. (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: Pre-mRNA-splicing factor SLU7; hSlu7
Additional info: This peptide can be used with studies using BS5936 SLU7 pAb.

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