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SMIF (S133) Peptide

Cat no: BS2145P

SMIF (S133) Peptide

Signal transduction of TGF-beta superfamily members is regulated by Smad proteins. In particular, Smads influence specific gene transcription by relaying signals from the cell membrane to the nucleus. Smad4 plays an essential role in TGF-beta-induced transcriptional activation wherein phosphorylated receptor-associated Smads associate with Smad4. Furthermore, SMIF (Smad4-intereacting protein) and Smad4 complex with TGF-beta and BMP4. An increase in Smad4 concentration increases the translocation of this complex to the nucleus. SMIF and Smad4 interact directly through a EVH1/WH1 domain on SMIF and a proline-rich activation domain on Smad4. Smad4 is essential to nuclear translocation of SMIF as deletion of the Smad4-interacting domain (located in the N-terminal 100 amino acids) of SMIF eliminates TGF-beta-induced nuclear translocation of SMIF (1). The human SMIF gene is ubiquitously expressed and encodes a protein with a relative molecular mass of 70 kDa.

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SPECIFICATIONS

Catalog Number

BS2145P

Applications

BNI

Form

1 mg/ml in DI water.

Purity

Synthetic peptide SMIF (S133). (Note: the amino acid sequence is proprietary). The purity is > 98%.

Swiss Prot

Q9NPI6

Storage Temp

Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Additional Info

This peptide can be used with studies using BS2145 SMIF (S133) pAb.

Alternative Names

EC 3.-.-.-; Transcription factor SMIF; Smad4-interacting transcriptional co-activator; DCP1A; HSA275986. Nbla00360. SMAD4IP1. SMIF

SUPPLIER INFO

Bioworld Technology, Inc.

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