SMNDC1 pAb

SPF30 (survival of motor neuron-related-splicing factor 30), also known as SMNDC1 (survival motor neuron domain containing 1) or SMNR (SMN-related protein), is an essential splicing factor required for spliceosome assembly that belongs to the SMN family. It contains one Tudor domain with significant similarity to SMN (Survival Motor Neuron) and is expressed in skeletal muscle, pancreas and heart, localizing to Cajal bodies and nuclear speckles. SPF30 plays an important role in spliceosome assembly and directly interacts with five U snRNPs. The loss of SPF30 causes spliceosome assembly to arrest at prespliceosomes (A complex). This supports a function for SPF30 in mediating the incorporation/recruitment of U4/U5/U6 tri-snRNP to the prespliceosome. In addition, the overexpression of SPF30 can lead to apoptosis.

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SPECIFICATIONS

Catalog Number

BS6029

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human SMNDC1.

Species

SMNDC1 pAb detects endogenous levels of SMNDC1 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

O75940

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 27 kDa

Alternative Names

30 a splicing factor SMNrp; \nMGC106917; \nMGC112663; \nSMN related protein; \nSMN-related protein; \nsmndc1; \nSMNR; \nSPF30; \nSPF30; \nSplicing factor 30; survival of motor neuron-related; \nSurvival motor neuron domain containing 1; \nSurvival motor neuron domain containing protein 1; \nSurvival motor neuron domain-containing protein 1; \nSurvival of motor neuron related splicing factor 30; \nSurvival of motor neuron-related-splicing factor 30; \n