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SMYD2 mAb

Cat no: MB0147

SMYD2 mAb

SMYD2 (SET and MYND domain containing 2), also known as KMT3C, HSKM-B or ZMYND14, is a 433 amino acid protein that contains one SET domain and one MYND-type zinc finger. Expressed at high levels in liver, heart, kidney, ovary and brain, SMYD2 functions as a lysine methyltransferase that, via methylation of p53, may play a role in repressing p53-mediated transcriptional regulation. The gene encoding MSYD2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome.

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SPECIFICATIONS

Catalog Number

MB0147

Size

100ug/100ul

Applications

WB

Hosts

Mouse

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human SMYD2.

Species

This antibody detects endogenous levels of SMYD2 and does not cross-react with related proteins

Dilutions

WB: 1:1000

Swiss Prot

Q9NRG4

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

Predicted band size:50KDa \nObserved band size:50KDa

Alternative Names

HSKM-B; Histone methyltransferase SMYD2,EC=2.1.1.43; Lysine N-methyltransferase 3C; SET and MYND domain-containing protein 2; KMT3C; HSKM-B; ZMYND14

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