SNX6 (SNX6, Sorting nexin-6, TRAF4-associated factor 2)

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with the long isoform of the leptin receptor, the transforming growth factor-beta family of receptor serine-threonine kinases, and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor. This protein may form oligomeric complexes with family member proteins through interactions of both the PX domain and the coiled coil regions of the molecules. Translocation of this protein from the cytoplasm to the nucleus occurs after binding to proviral integration site 1 protein. This gene results in two transcripts encoding two distinct isoforms.\n\nApplications:\nSuitable for use in Western Blot, ELISA.\n\nRecommended Dilution:\nELISA: 1:1000\nWestern Blot: 1:100~500\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage, store at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

031253

Size

200ul

Applications

ELISA, WB

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.

P Type

Mab

Purity

Purified by Protein G affinity chromatography.

Isotype

IgG1,k

References

Okada, H., et al. FASEB J. 24(8):2783-2794(2010)\nHong, Z., et al. Cell Res. 19(12):1334-1349(2009)\nWassmer, T., et al. J. Cell. Sci. 120 (PT 1), 45-54 (2007)\nCamargo, L.M., et al. Mol. Psychiatry 12(1):74-86(2007)\nIshibashi, Y., et al. FEBS Lett. 506(1):33-38(2001)

Additional Info

Human

Alternative Names

SNX6, Sorting nexin-6, TRAF4-associated factor 2