Home  >  Products  >  SOCS1 (Suppressor of Cytokine Signaling 1, Tec-interacting Protein 3, TIP-3, STAT-induced STAT Inhibitor 1, SSI-1, JAK-binding Protein, JAB, Suppressor of Cytokine Signaling 1, SOCS-1, SSI1, TIP3)
SOCS1 (Suppressor of Cytokine Signaling 1, Tec-interacting Protein 3, TIP-3, STAT-induced STAT Inhibitor 1, SSI-1, JAK-binding Protein, JAB, Suppressor of Cytokine Signaling 1, SOCS-1, SSI1, TIP3)

SOCS1 (Suppressor of Cytokine Signaling 1, Tec-interacting Protein 3, TIP-3, STAT-induced STAT Inhibitor 1, SSI-1, JAK-binding Protein, JAB, Suppressor of Cytokine Signaling 1, SOCS-1, SSI1, TIP3)

Cat no: S1040-01X

Supplier: United States Biological
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The Suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins, which regulate the immune cell responses to cytokines. SOCS1 acts to suppress dendritic cell (DC) as well as T cell hyperactivation following cytokine signaling by inhibiting JAK tyrosine kinase, a kinase necessary for type I and II cytokine receptors to initiate signaling, by directly binding to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP. Applications: Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: ELISA: 1:4000 Western Blot: 1-3ug/ml Immunohistochemistry (Paraffin): 2-3ug/ml Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Catalogue number: S1040-01X
Reactivities: Human, Mouse, Rat, Bovine, Canine
Hosts: Goat
Applications: ELISA, Immunohistochemistry, Western Blot
Size: 100ug
Form: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.
P type: Pab
Purity: Purified by immunoaffinity chromatography.
References: 1. Starr R, Willson TA, Viney EM, Murray LJ, Rayner JR, Jenkins BJ, Gonda TJ, Alexander WS, Metcalf D, Nicola NA, Hilton DJ. A family of cytokine-inducible inhibitors of signalling. Nature 1997 Jun 26;387(6636):917-21.
Additional info: Recognizes human SOCS1. Species Crossreactivity: mouse. Species sequence homology: Bovine, canine and rat.

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