Somatostatin is a regulatory hormone that plays an inhibitory role in a variety of organ systems. This cyclic tetradecapeptide inhibits the secretion of many important hormones, including somatotropin (also designated growth hormone, or GH), Insulin and Glucagon. Somatostatin is found in both the hypothalamus and in the pancreas. Somatostatin is thought to be involved in the regulation of insulin synthesis. In the cerebellum, two processed forms, Somatostatin-14 and Somatostatin-28, are highly expressed at birth and in the adult stage, respectively. The gene encoding Somatostatin maps to human chromosome 3q28.