Spectrin (beta) II (M687) pAb

Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin (alpha) I and spectrin (beta) I are present in erythrocytes, whereas spectrin (alpha) II (also designated fodrin (alpha)) and spectrin (beta) II (also designated fodrin (beta)) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin (beta) I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of (beta)-spectrin.

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SPECIFICATIONS

Catalog Number

BS3402

Size

100ug/100ul

Applications

WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Synthetic peptide, corresponding to amino acids 650-700 of Human Spectrin (beta) II.

Species

Spectrin (beta) II (M687) pAb detects endogenous levels of Spectrin (beta) II protein.

Dilutions

WB: 1:500~1:1000

Swiss Prot

Q01082

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul