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Spectrin beta II (M687) Peptide

Spectrin beta II (M687) Peptide

Cat no: BS3402P

Supplier: Bioworld Technology, Inc.
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Spectrin is an actin binding protein that is a major component of the cytoskeletal superstructure of the erythrocyte plasma membrane. Spectrins function as membrane organizers and stabilizers by forming dimers, tetramers and higher polymers. Spectrin alpha I and spectrin beta I are present in erythrocytes, whereas spectrin alpha II (also designated fodrin alpha) and spectrin beta II (also designated fodrin beta) are present in other somatic cells. The spectrin tetramers in erythrocytes act as barriers to lateral diffusion, but spectrin dimers seem to lack this function. Defects in the SPTB gene encoding spectrin beta I are the cause of spherocytosis type I (SPH1), a disorder characterized by severe hemolytic anemia. Another disorder due to defects of SPTB is called elliptocytosis or elliptocytosis 3 (EL3). The human SPTB gene maps to chromosome 14q22-q23.2 and encodes the 2,137 amino acid, 246 kDa erythroid form of beta-spectrin.
Catalogue number: BS3402P
Applications: Block/Neutralize/Inhibit
Swiss prot: Q01082
Form: 1 mg/ml in DI water.
Purity: Synthetic peptide Spectrin beta II (M687). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names: SPTBN1; SPTB2; Fodrin beta chain; Beta-II spectrin; Spectrin, non-erythroid beta chain 1
Additional info: This peptide can be used with studies using BS3402 Spectrin beta II (M687) pAb.

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