SPRR3 (Small Proline-rich Protein 3)

The formation of the cornified (CE) envelope during the late stages of epidermal differentiation is essential for epidermal barrier function and protects the body against environmental attack and water loss. Formation of the cornified envelope involves the replacement of the plasma membrane by cross-linkage of precursor proteins such as loricrin, involucrin and small proline rich proteins (SPRR). SPRR genes constitute a multigene family clustered within the epidermal differentiation complex on chromosome 1q21. This cluster contains two SPRR1 genes, seven SPRR2 genes and a single SPRR3 gene. SPRR gene products are differentially expressed in vivo and in vitro suggesting that the SPRR multigene family evolved to provide highly specialized cornified envelope precursor proteins in stratified epithelia. SPRR2 is mainly expressed in interfollicular epidermis.\n\nApplications:\nSuitable for use in Immunocytochemistry, Immunohistochemistry, Western Blot\n\nRecommended Dilution:\nOptimal dilutions to be determined by researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

045310

Size

100ul

Applications

ICC, IHC, WB

Hosts

Rabbit

Form

Neat serum 0.02% sodium azide.

P Type

Pab

References

Product Reference: \n?The small proline-rich proteins constitute a multigene family of differentially regulated cornified cell envelope precursor proteins: D. Hohl, et al.; J. Invest. Dermatol. 104, 902 (1995)\n?Expression of small proline rich proteins in neoplastic and inflammatory skin diseases: M. De Heller-Milev, et al.; Br. J. Dermatol. 143, 733 (2000)\n?

Additional Info

Recognizes human SPRR3. Does not cross-react with SPRR1 or SPRR2.

Alternative Names

Small Proline-rich Protein 3