SST (SMST, somatostatin-28, Growth hormone release-inhibiting factor)

SST (Somatostatin), also known as SMST, is a peptide hormone. Naylor et al. (1983) assigned the somatostatin gene to chromosome 3 by analyzing somatic cell hybrids with a polymorphic gene probe. Yacubova and Komuro (2002) examined the effects of somatostatin in cerebellar granule cells of early postnatal mice, because these cells express all 5 types of somatostatin receptors before the initiation of their migration. Saito et al. (2005) found that somatostatin modulated the proteolytic degradation of beta-amyloid catalyzed by neprilysin both in vitro and in vivo.\n\nUniProt Number:\nP61278\n\nGene ID:\nSST\n\nApplications:\nSuitable for use in Western Blot and Immunohistochemistry (Paraffin).\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Handling:\nStore at -20?C for one year. After reconstitution, store at 4?C for one month. Can also be aliquoted and stored frozen at -20?C for long term.\nAvoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Prices direct from United States Biological

Quick response times

Exclusive Biosave savings/discounts

SPECIFICATIONS

Catalog Number

145220

Size

100ug

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

Supplied as a lyophilized powder. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3. Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Naylor, S. L., Sakaguchi, A. Y., Shen, L.-P., Bell, G. I., Rutter, W. J., Shows, T. B. Polymorphic human somatostatin gene is located on chromosome 3. Proc. Nat. Acad. Sci. 80: 2686-2689, 1983. \n2. Saito, T., Iwata, N., Tsubuki, S., Takaki, Y., Takano, J., Huang, S.-M., Suemoto, T., Higuchi, M., Saido, T. C. Somatostatin regulates brain amyloid beta-peptide A-beta-42 through modulation of proteolytic degradation. Nature Med. 11: 434-439, 2005. \n3. Yacubova, E., Komuro, H. Stage-specific control of neuronal migration by somatostatin. Nature 415: 77-81, 2002.\n

Additional Info

Recognizes human,mouse and rat SST. No crossreactivity with other proteins.