STAM2 (Signal Transducing Adapter Molecule 2, Signal Transducing Adaptor Molecule 2, STAM-2, STAM2A, STAM2B, DKFZp564C047, Hrs-binding Protein, HBP, STAM-like Protein Containing SH3 and ITAM Domains 2)

STAM2 (signal transducing adapter molecule 2), a ubiquitously expressed protein and member of the STAM family, involved in cytokine-mediated signal transduction, downstream of JAK kinases. STAM2 is involved in mediating the endocytic sorting of ubiquitinated membrane proteins on early endosomes, binding directly with ubiquitin, and co-localizing with Hrs (hepatocyte growth factor-regulated tyrosine kinase substrate) and Eps15 (epidermal growth factor receptor substrate 15), in clathrin-containing endosomal microdomains.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 1-3ug/ml\nOptimal dilutions to be determined by the researcher.\n\nPositive Control:\nHuman Spleen lysate\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S7954-10B

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Hum

Form

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Kobayashi H, Tanaka N, Asao H, Miura S, Kyuuma M, Semura K, Ishii N, Sugamura K. Hrs, a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal transducing adaptor molecule 1 and 2. J Biol Chem. 2005 Mar 18;280(11):10468-77. Epub 2005 Jan 7. PMID: 15640163

Additional Info

Recognizes human STAM2. Species sequence homology: canine, mouse.

Alternative Names

Signal Transducing Adaptor Molecule (SH3 Domain and ITAM Motif) 2, Signal Transducing Adaptor Molecule 2A, Signal Transducing Adaptor Molecule 2B