Stanniocalcin 1 (STC-1)

Stanniocalcin 1 (STC1) is the mammalian homologue of STC, which was originally identified as a calcium/phosphate -regulating hormone in bony fishes. In contrast, STC1 may play an autocrine and paracrine role with pleiotropic effects in mammals. It is expressed in a wide variety of tissues, but unexpectedly is not detected in the circulation under normal circumstances, possibly caused by its attaching to soluble and tethered forms of a high-affinity binding protein. STC-1 can affect calcium homeostasis, bone and muscle mass and structure, and angiogenesis through effects on osteoblasts, osteoclasts, myoblasts/myocytes, and endothelial cells in mouse model. Differential regulation of myocardial STC1 protein expression was reported in heart failure. STC1 may regulate calcium currents in cardiomyocytes and may contribute to the alterations in calcium homeostasis of the failing heart. STC1 was found to be a selective modulator of hepatocyte growth factor (HGF)-induced endothelial migration and morphogenesis, an inhibitor of macrophage chemotaxis and chemokinesis, suppressor of progesterone and luteinization inhibitor. In terminally differentiated adipocytes, it may function as a survival factor, which contributes to the maintenance of the integrity of mature adipose tissue. STC1 was identified as one of hypoxia-responsive genes coupled to hypoxia-driven angiogenesis. STC1 is a useful molecular marker to detect tumor cells in blood and bone marrow from patients with various types of malignancies. \n\nApplications:\nSuitable for use in ELISA and Western Blot. Other applications not tested.\n\nRecommended Dilution:\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stabillty:\nLyophilized powder may be stored at -20 degrees C. Stable for 12 months at -20 degrees C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S7958-49

Size

100ug

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a lyophilized powder in PBS, pH 7.2. No preservative added. Reconstitute with 100ul sterile dH2O. Let the lyophilized pellet dissolve completely.

P Type

Pab

Purity

Purified by Immunoaffinity chromatography.

Isotype

igG

References

1. Fujiwara Y, et al., Assessment of Stanniocalcin-1 mRNA as a molecular marker for micrometastases of various human cancers. 2. McCudden CR, et al., Co-localization of stanniocalcin-1 ligand and receptor in human breast carcinomas. 3. James K, et al., Evidence for stanniocalcin binding activity in mammalian blood and glomerular filtrate. 4. Xiao LJ, et al., Expression and regulation of stanniocalcin 1 and 2 in rat uterus during embryo implantation and decidualization. \n5. Yeung HY, et al., Hypoxia-inducible factor-1-mediated activation of stanniocalcin-1 in human cancer cells. 6. Hasselblatt M, et al., Identification of novel diagnostic markers for choroid plexus tumors: a microarray-based approach. 7. Hasilo CP, et al., Nuclear targeting of stanniocalcin to mammary gland alveolar cells during pregnancy and lactation. 8. Yoshiko Y, et al., Stanniocalcin 1 (STC1) protein and mRNA are developmentally regulated during embryonic mouse osteogenesis: the potential of stc1 as an autocrine/paracrine factor for osteoblast development and bone formation. \n\n\n9. Wu S, Yoshiko Y, De Luca F. Stanniocalcin 1 acts as a paracrine regulator of growth plate \nchondrogenesis. \n10. Filvaroff EH, Guillet S, Zlot C, Bao M, Ingle G, Steinmetz H, Hoeffel J, Bunting S, Ross J, Carano RA, \nPowell-Braxton L, Wagner GF, Eckert R, Gerritsen ME, French DM. Stanniocalcin 1 alters muscle \nand bone structure and function in transgenic mice. \n11. Zlot C, Ingle G, Hongo J, Yang S, Sheng Z, Schwall R, Paoni N, Wang F, Peale FV Jr, Gerritsen ME. \nStanniocalcin 1 is an autocrine modulator of endothelial angiogenic responses to hepatocyte \ngrowth factor. \n12. Yoshiko Y, Maeda N, Aubin JE. Stanniocalcin 1 stimulates osteoblast differentiation in rat \ncalvaria cell cultures. \n13. Tohmiya Y, Koide Y, Fujimaki S, Harigae H, Funato T, Kaku M, Ishii T, Munakata Y, Kameoka J, \nSasaki T. Stanniocalcin-1 as a novel marker to detect minimal residual disease of human \nleukemia. \n14. Sheikh-Hamad D, Bick R, Wu GY, Christensen BM, Razeghi P, Poindexter B, Taegtmeyer H, \nWamsley A, Padda R, Entman M, Nielsen S, Youker K. Stanniocalcin-1 is a naturally occurring L- \nchannel inhibitor in cardiomyocytes: relevance to human heart failure. \n15. Kanellis J, Bick R, Garcia G, Truong L, Tsao CC, Etemadmoghadam D, Poindexter B, Feng L, \nJohnson RJ, Sheikh-Hamad D. Stanniocalcin-1, an inhibitor of macrophage chemotaxis and \nchemokinesis. \n16. Wascher RA, Huynh KT, Giuliano AE, Hansen NM, Singer FR, Elashoff D, Hoon DS. Stanniocalcin- \n1: a novel molecular blood and bone marrow marker for human breast cancer. \n17. Jiang WQ, Chang AC, Satoh M, Furuichi Y, Tam PP, Reddel RR. The distribution of stanniocalcin \n1 protein in fetal mouse tissues suggests a role in bone and muscle development. \n18. Lal A, Peters H, St Croix B, Haroon ZA, Dewhirst MW, Strausberg RL, Kaanders JH, van der Kogel \nAJ, Riggins GJ. Transcriptional response to hypoxia in human tumors. \n19. Serlachius M, Andersson LC. Upregulated expression of stanniocalcin-1 during adipogenesis.

Additional Info

Recognizes human STC-1.