Stat 5 (Signal Transducer and Activator of Transcription 5, STAT5, Mammary Gland Factor, MGF, Signal Transducer and Activator of Transcription 5A, STAT5A, STAT5B, Transcription Factor STAT5A)

A variety of cytokines and growth factors act through an induction of gene expression mediated by a family of latent transcription factors called STAT (Signal Transducers and Activators of Transcription) proteins. Cytokines, hormones and growth factors proceed through a sequence of steps that includes binding to receptors in the cytokine receptor superfamily followed by the activation of the JAK family of tyrosine kinases, which results in the activation of STAT proteins. The activated STATs then become dimerized and translocated into the nucleus where they initiate specific gene transcription. STAT 5 regulates growth, differentiation, and survival of mammary, hematopoietic cells, hematopoietic malignancies, or carcinogenesis. Constitutive activation of STAT 5 may contribute to tumorigenesis, thus dephosphorylation of STAT 5 may serve as a therapeutic strategy.\n\nApplications:\nSuitable for use in Western Blot. Other applications not tested.\n\nRecommended Dilution:\nWestern Blot: 0.5-2ug/ml\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S7972-07L2

Size

50ug

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS, pH 7.4, 0.05% sodium azide.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG

References

1. Stancato, L. et al. J Biol Chem 271, 4134 (1996) 2. Su, L. et al. J Biol Chem 274, 31770 (1999) 3. Dimberg, A. et al. Blood 102, 254 (2003) 4. Maurer, A. et al. Blood 99, 2647 (2002).

Additional Info

Recognizes human STAT5.