STAT 5b, phosphorylated (Ser133) (Signal Transducer and Activator of Transcription 5b)

STAT (signal transducers and activators of transcription) can be selectively phosphorylated on tyrosine and serine residues. The STAT proteins are highly conserved in their amino termini, but have divergent carboxy termini, thought to be essential for their selective activity. STAT5 can be activated by a variety of different agents including prolactin, IL-2, IL-3, IL-7, IL-5, growth hormone and erythropoietin. The highly homologous STAT 5a and STAT 5b proteins are essential mediators of prolactin and growth hormone effects and have been implicated in physiological functions including cytokine control of apoptosis, growth, reproduction, lactation, immune function, differentiation and somatic growth.\n\nApplications: \nSuitable for use in ELISA. Other applications not tested.\n \nRecommended Dilution:\nIndirect ELISA: 1ug/ml of peptide/or peptide conjugate in pH 9.5 carbonate buffer, 100ul/well \nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degrees C. Reconstituted product is stable for 24 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S7972-15L

Size

500ug

Applications

ELISA

Hosts

Mouse

Reactivities

Hum

Form

Supplied as a lyophilized powder from a solution of 0.01M PBS, pH7.0. Reconstitution: Double distillated water is recommended and to adjust the final concentration to 1mg/ml.

P Type

Mab

Purity

Purified by immunoaffinity chromatography.

Isotype

IgG1,k

Additional Info

Reactive to the immunogen human STAT5b, phosphorylated (pS133) (Signal Transducers and Activators of Transcription 5b), peptide-BSA conjugating and peptide in ELISA.