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STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal Transducer and Activator of Transcription 6)

Cat no: S7972-42D

STAT 6 (STAT6B, STAT6C, D12S1644, IL-4-STAT, interleukin 4 induced STAT, Signal Transducer and Activator of Transcription 6)

STAT6 is a latent cytosolic transcription factor which becomes activated following phosphorylation by JAK1 and JAK3, in response to IL-4 and IL-13. Upon activation, STAT6 proteins form homodimers which translocate to the nucleus. STAT6 is critical for the expression of many IL-4 and IL-13 responsive genes, including class II major histocompatibility molecules, CD23 and IL-1Ra. It also plays an important role in Th2 differentiation, IgE class switching and inflammation.\n\nApplications:\nSuitable for use in Western Blot. Immunoprecipitation and Immunohistochemistry (Frozen). Other applications not tested. \n\nRecommended Dilution: \nWestern Blot: 1: 1.000-1: 10,000\nImmunoprecipitation: 1-4ug/mg protein\nOptimal dilution determined by the researcher.\n\nRecommended Secondary Reagents: \nSheep anti rabbit IgG: HRP\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degrees C. Aliquots are stable for at least 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S7972-42D

Size

50ug

Applications

IHC, IP, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

Form

Supplied as a liquid in PBS, pH 7.4, 0.02% sodium azide.

P Type

Pab

Purity

Purified by affinity chromatography.

Additional Info

Specific for human STAT6 (signal transducer and activator of transcription 6).\nSpecies Cross Reactivity: Mouse

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