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Stat5b (Y725) pAb

Stat5b (Y725) pAb

Cat no: BS1711

Supplier: Bioworld Technology, Inc.
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Stat5a and Stat5b (signal transducer and activator of transcription 5a and 5b; 96% homology) undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7, GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Activation of Stat5b via IL-2, IL-4, CSF1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with retinoic acid receptor-(alpha) gene in acute promyelocytic leukemias (APLL).
Catalogue number: BS1711
Reactivities: Human, Mouse, Rat
Hosts: Rabbit
Applications: Immunohistochemistry, Western Blot
Size: 100ug/100ul
Swiss prot: P51692
Dilutions: WB: 1:500~1:1000 IHC: 1:50~1:200
Form: liquid
Storage buffer: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
Concentration: 1ug/ul
Antigen: Synthetic peptide, corresponding to amino acids 700-750 of Human Stat5b.
Species: Stat5b (Y725) pAb detects endogenous levels of Stat5b protein.
Molecular weight: ~ 90 kDa
Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Storage temp: Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.
Alternative names: Signal transducer and activator of transcription 5B; STA5B; STAT5; Stat5b; Transcription factor STAT5B;
Additional info: For research use only, not for use in diagnostic procedure.

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