STEAP3 pAb

pHyde has a potential role as a tumor suppressor by inducing caspase-3-mediated apoptosis and stimulating p53 expression. A dose-dependent increase in caspase-3 activity is observed in transduced pHyde DU145 cells. Furthermore, caspase-3 may be necessary for pHyde-mediated apoptosis. The pHyde gene may upregulate the apoptosis pathway and thus have a potential application in cancer gene therapy. Recombinant pHyde inhibits the growth of human prostate cancer cell lines DU145 and LNCaP in vitro. DU145 tumors may be reduced significantly in vivo when nude mice are injected with recombinant pHyde. pHyde also has a demonstrated growth inhibitory effect on human breast cancer cells. This suggests that pHyde may have a role in inhibiting different tumor types.

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SPECIFICATIONS

Catalog Number

BS6032

Size

100ug/100ul

Applications

IHC, WB

Hosts

Rabbit

Reactivities

Hum, Mouse, Rat

Form

liquid

Purity

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Antigen

Recombinant full length Human STEAP3.

Species

STEAP3 pAb detects endogenous levels of STEAP3 protein.

Dilutions

WB: 1:500~1:2000\nIHC: 1:50~1:200

Swiss Prot

Q658P3

Storage Temp

Store at 4 degrees C short term. Aliquot and store at -20 degrees C long term. Avoid freeze-thaw cycles.

Concentration

1ug/ul

Storage Buffer

1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Additional Info

For research use only, not for use in diagnostic procedure.

Molecular Weight

~ 55 kDa

Alternative Names

1010001D01Rik; \nDudlin 2; \nDudlin2; \nDudulin 2; \nDudulin-2; \nDudulin2; \nhpHyde; \nhTSAP6; \nMetalloreductase STEAP3; \nMGC93147; \npHyde; \nSix transmembrane epithelial antigen of prostate 3; \nSix transmembrane prostate protein 3; \nSix-transmembrane epithelial antigen of prostate 3; \nSTEA 3; \nSTEA3; \nSTEAP 3; \nSTEAP family member 3; \nSTEAP family member 3 metalloreductase; \nSTEAP3; \nSTMP 3; \nSTMP3; \nTSAP 6; \nTSAP6; \nTumor suppressor activated pathway protein 6; \nTumor suppressor pHyde; \nTumor s