STK36 (Serine/Threonine Kinase 36, Fused Homolog (Drosophila), DKFZp434N0223, FU, KIAA1278, fused, serine/threonine kinase 36)

Serine/threonine protein kinase required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur.\n\nApplications:\nSuitable for use in ELISA. Other applications not tested.\n\nRecommended Dilution:\nELISA: 1:16,000\nOptimal dilutions to be determined by the researcher.\n\nStorage and Stability:\nMay be stored at 4 degrees C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degrees C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

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SPECIFICATIONS

Catalog Number

S7973-59C

Size

100ug

Applications

ELISA

Hosts

Goat

Reactivities

Hum

Form

Supplied as liquid 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% BSA.

P Type

Pab

Purity

Purified by affinity chromatography.

Isotype

IgG

References

1. Maloveryan A, Finta C, Osterlund T, Kogerman P. A possible role of mouse Fused (STK36) in Hedgehog signaling and Gli transcription factor regulation. Journal of Cell Communication and Signaling 2007 Dec 1 (3-4): 165-73.

Additional Info

Recognizes STK36. Sequence homology: human, canine.