Superoxide Dismutase 1 (SOD1)

Supplier:

United States Biological

Cat no: S8060-30A

Superoxide Dismutase 1 (SOD1)

Superoxide Dismutases (SODs), originally identified as Indophenoloxidase (IPO), are enzymes that catalyze the converversion of naturally-occuring but harmful superoxide radicals into molecular oxygen and hydrogen peroxide. Superoxide Dismutases 1, SOD1, also known as Cu/Zn SOD, soluble SOD, and IPO-A, is a soluble, cytoplasmic 16 kD homodimer. Each SOD1 monomer binds one Cu 2 and Zn 2 ion. Three isozymes of SOD have been identified and are functionally related but have very modest sequence homology. SOD1 shares 23% and 27% sequence identity with SOD2 and SOD3, respectively. Mutations in SOD1 have been suggested to be the cause of familial amyotrophic lateral sclerosis (ALS). The ALS-causing mutations of SOD1 are scattered throughout the protein and provide no clear functional or structural clues to the underlying disease mechanism. The oligomerization hypothesis suggests that mutant SOD1 proteins become misfolded and consequently oligomerize into high molecular weight aggregates that result in the death of motor neurons. The oxidative damage hypothesis suggests that loss of function mutations in SOD1 result in the intracellular accumulation of the superoxide radical, leading to free radical-mediated damage, the release of cytochrome c, and apoptosis.\n\nApplications: \nSuitable for use in Western Blot and ELISA. Other applications not tested.\n\nRecommended Dilution: \nELISA: 0.5-1ug/ml \nWestern Blot: 1-2ug/ml \nOptimal dilutions to be determined by the researcher.\n\nReconstitution \nReconstitute the antibody in 100 microL PBS containing 0.02% NaN3. The antibody \nconcentration will be 1.0 mg/mL.\n\nStorage and Stability:\nLyophilized powder may be stored at 4 degrees C for short-term only. Reconstitute to nominal volume by adding sterile PBS with 40-50% glycerol and store at -20 degrees C. Reconstituted product is stable for 12 months at -20 degrees C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

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SPECIFICATIONS

Catalog Number

S8060-30A

Size

100ug

Applications

WB

Hosts

Goat

Reactivities

Mouse, Rat

Form

Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose.

P Type

Pab

Purity

Purified by mouse SOD1 affinity chromatography.

Isotype

IgG

Additional Info

Recognizes mouse SOD1. Species Crossreactivity: Rat.

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SUPPLIER INFO

United States Biological

Address:

4 Technology Way, Salem, MA 01970, US

Phone:

+1 800 520 3011

Website:

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