SURF-1 (F181) Peptide

Cat no: BS2068P

Supplier: Bioworld Technology, Inc.

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The SURF-1 protein demonstrates a vital role in the assembly of complex IV (CIV or COX) of the mitochondrial respiratory chain. Expressed in the inner mitochondrial membrane, mutations of the SURF-1 gene generally cause cytochrome c oxidase complex IV deficiency. Shortage of complex IV leads to Leigh syndrome, a severe neurological disorder. Leigh syndrome patients are usually subject to rapidly progressive encephalopathy, characterized by necrotic lesions in subcortical brain regions. SURF-1 mutations correlate to high post-implantation embryonic lethality as well as early-onset mortality of post-natal individuals. Considerable deficit in muscle strength and motor performance is also a profound and isolated defect of SURF-1 activity in skeletal muscle and liver. Heart, brain and skeletal muscle morphological abnormalities frequently occur due to SURF-1 mutations.

Catalogue number:	BS2068P
Applications:	Block/Neutralize/Inhibit
Swiss prot:	Q15526
Form:	1 mg/ml in DI water.
Purity:	Synthetic peptide SURF-1 (F181). (Note: the amino acid sequence is proprietary). The purity is > 98%.
Storage temp:	Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Alternative names:	SURF 1; SURF-1; Surf1; SURF1; Surfeit 1; Surfeit locus protein 1;
Additional info:	This peptide can be used with studies using BS2068 SURF-1 (F181) pAb.

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SURF-1 (F181) Peptide

Cat no: BS2068P

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