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Survivin, Recombinant, Human (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4)

Cat no: S8500-02H

Survivin, Recombinant, Human (Apoptosis Inhibitor 4, Apoptosis Inhibitor-4, API4, Apoptosis Inhibitor Survivin, Baculoviral IAP Repeat-containing 5, BIRC5, BIRC-5, EPR1, EPR-1, IAP4)

Survivin, a member of the inhibitor of apoptosis (IAP) family, is also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5 and in humans is encoded by the BIRC5 gene. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis. Disruption of survivin induction pathways leads to an increase in apoptosis and decrease in tumor growth. Survivin is highly expressed in most human tumors and fetal tissue, but is completely absent in terminally differentiated cells, making survivin an ideal target for studying cancer therapy.\n\nSource:\nRecombinant human Survivin expressed in E. coli.\n\nAccession #: \nO15392, with two mutations (A128V and E129K) underlined below and an N-terminal His-tag\n\nSequence: \nMGSSHHHHHHSSGLVPRGSHMGAPTLPPAWQPFLKDh RISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFCFKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNKKKEFEETVKKVRRAIEQLAAMD \n\nStorage and Stability:\nAliquot and Store at

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SPECIFICATIONS

Catalog Number

S8500-02H

Size

10ug

Form

Sterile filtered and lyophilized with no additives. Reconstitute to a concentration of 0.1-1mg/ml in PBS.

Purity

~90% as determined by SDS-PAGE. Endotoxin: Less than 0.1ng/ug of human Survivin.

Alternative Names

SVV, TIAP

Read more on Supplier website

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

More info

Applications

ELISA, WB

Hosts

Rabbit

Reactivities

Hum, Mouse

More info
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