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Syk, phosphorylated (Tyr323)

Cat no: S9100-01C

Syk, phosphorylated (Tyr323)

Syk (72kD) is a non-receptor protein tyrosine kinase that plays a central role in immune receptor signal transduction and is implicated in endothelial cell functions, including cell growth and migration. Syk is activated upon binding to immunoreceptor tyrosine-based activating motif (ITAM) and involved in coupling activated immunoreceptors to downstream signaling. Syk undergoes phosphorylation on multiple tyrosines within the linker region that separates the Cterminal catalytic domain from the N-terminal SH2 domains (tyrosines 323, 348 and 352 or 317, 342 and 346 using the mouse sequence). The phosphorylation of Syk tyrosine 323

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SPECIFICATIONS

Catalog Number

S9100-01C

Size

10 Blots

Applications

WB

Hosts

Rabbit

Reactivities

Hum

Form

Supplied as a liquid in PBS (without Mg2+ and Ca2+), 1mg/ml BSA (IgG, protease free), pH 7.2, 0.05% sodium azide, 50% glycerol.

P Type

Pab

Purity

Purified by immunoaffinity chromatography.

References

1. Mocsai, A., et al. (2004) The immunomodulatory adapter proteins DAP12 and Fc receptor {gamma}-chain (FcR{gamma}) regulate development of functional osteoclasts through the Syk\ntyrosine kinase. Proc. Nat

Additional Info

Recognizes human Syk when phosphorylated at Tyr323. Species sequence homology: Mouse Syk phosphorylated at Tyr317 (79%).

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